Wednesday, 30 March 2011

Brain Function

Probably the greatest fear about growing old is the possibility of serious mental decline: forgetting things, being
confused in public, and much worse. The extent to which this really happens, and especially the time of onset of the decline, is a subject of debate. Whatever the details may be, however, and judging again by animal data, the decline can be slowed, even largely prevented, by the Anti-Aging Plan with caloric limitation.

Mental function in laboratory animals can be estimated by their ability to navigate a complicated maze or
labyrinth. How many trials does it take to learn when to choose this turn, that turn, and not end in blind alleys; and finally to arrive at the reward at the end of the maze? On such a test, a 32-month-old calorie-restricted mouse does as well as a 12-month-old ad lib mouse. This is roughly equivalent to a 75 year-old human showing the same speed of learning and same memory retention as a 25-year-old. And in rats the age-related slowdown in rate of learning and in memory utilization are largely eliminated by nutrient-rich caloric limitation.

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